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{ Author Archives }

Cryptosporidium parvum Mitochondrial-Type HSP70 Targets Homologous and Heterologous Mitochondria (Slapeta and Keithly, 2004)

In this article they describe a HSP70 gene that they call mitochondrial, but all they really can say is that it has an homology with a mitochondrial gene. Since they assume that this gene has been derived from an endosymbiont, this biases the entire article, but still they have some interesting results. They show that […]

The missing link between hydrogenosomes and mitochondria (Martin, 2005)

 This article argues that hydrogenosomes are derived from mitochondria. I don’t see anaerobic organisms as oxygen-’shunning’ and also not that without a doubt htey are mitochondria in the endosymbiotic sense. In the eukaryotic sense, yes. He seems to see the presence of DNA per se as good evidence for a derived mitochondrion, whereas in my opinion it […]

Hydrogenosomes: convergent adaptations of mitochondria to anaerobic environments (Hackstein et al., 2001)

This article from Johannes Hackstein (who did the genetics course in my first year of university, btw) is based on two assumptions that are taken for granted but with which I disagree. The first is the view that the anaerobic protists have adapted to this lyfestyle, while I think that they are representatives of a pre-aerobic world and […]

Electron Tomographic and Ultrastructural Analysis of the Cryptosporidium parvum Relict Mitochondrion, its Associated Membranes, and Organelles (Keithly et al., 2005)

This abstract shows that the Cryptosporidium mitochondrion is associated with the endoplasmic reticulum, and could be relevant for the origin of mitochondria if it represents an intermediate. An endomembrane-derived mitochondrion could be expected to associate with the ER. Here we can see the as well my proposed scenario for the origin of the nucleus and […]

Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum (Abrahamsen et al., 2004)

This article describes the genome sequence of Cryptosporidium which lacks a mitochondrial genome and is thus completely dependent on the eukaryotic nucleus. Their conclusion is that it has lost its genome and its mitochondrion is degenerate, which is again a pity since it becomes difficult to see what their real data is and what they […]

Organization of the Mitochondrial Genome in the Dinoflagellate Amphidinium cartera (Nash et al., 2007)

The dinoflagellate Amphidinium has just like Oxyrrhis only a few (3) mitochondrial genes as shown here (only abstract). It also describes the organization of the genome, with fragmented genes of the only 3 functional genes and a large number of inverted repeats. This is important for two reasons: 1) in an endosymbiotic origin I would expect […]

The Highly Reduced and Fragmented Mitochondrial Genome of the Early-branching Dinoflagellate Oxyrrhis marina Shares Characteristics with both Apicomplexan and Dinoflagellate Mitochondrial Genomes (Slamovits et al., 2007)

This is an article about the genome of the Dinoflagellate Oxyrrhis with a small genome. Keeling’s group keeps referring to it as reduced, but that only holds if the endosymbiotic theory is correct. The problem is that the entire article is based (biased) on this, which makes it difficult to assess its real value. What […]

Mitochondrial genome diversity: evolution of the molecular architecture and replication strategy (Nosek and Tomaska 2003)

This is a nice article that could explain the easy interconversion from circular to linear DNA. The plasmid or transposon that inserts itself in the circle automatically provides the protection against the end replication problem. The nuclear chromosomes have a complete machinery for this ‘task’ which make sit unlikely that their origin is the same. Anyway, […]

A Genome Phylogeny for Mitochondria Among alpha-Proteobacteria and a Predominantly Eubacterial Ancestry of Yeast Nuclear Genes (Esser et al., 2004)

This article that uses compares nuclear genes with prokaryotic genes in order to look at the origin of mitochondria. They have some interesting results, basically showing that many eukaryotic genes have a prokaryotic counterpart. Also, the trees are far from clear and interestingly, they use the endosymbiotic theory as a control for the data. So, […]

The dual origin of the yeast mitochondrial proteome. (Karlbert et al., 2000)

Andersson’s group here describes more data on Rickettsia and mitochondrial origin. He directly attributes homologous sequences to a alpha-proteo bacterial origin and assumes the endosymbiotic theory to be true and therefore all of his remarks has to be seen in this respect. He habitually mixes homology with origin, although phylogenetic analyses cannot give a direction […]